解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Addition of phenylbutazone (2 mg/ml) to 55 vol% of fresh defibrinated human blood permitted leukocytic ingestion of Serratia marcescens bacteria, but blocked phagocytic killing activity. The group A (phage tail) bacteriocin bA+ 16 served to kill extraphagocytic test bacteria. Five bacterial DNA gyrase inhibitors (cipr...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238297
更新日期:1984-01-01 00:00:00
abstract::The in vitro activity of ceftazidime has been compared with those of cephalothin, cefuroxime, and netilmicin against a variety of gram-positive and gram-negative bacteria in order to register sensitivity patterns in the western part of Norway. An agar dilution method was used for minimal inhibitory concentration (MIC)...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238256
更新日期:1984-01-01 00:00:00
abstract::The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram-negative bacilli was investigated using the quantitative plate dilution method. Result...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238243
更新日期:1984-01-01 00:00:00
abstract::Mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to Morganella morganii. This combination showed in vitro synergy as measured by the checkerboard technique. A marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting str...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238267
更新日期:1984-01-01 00:00:00
abstract::Rifampicin and rifapentine were used in the treatment of Listeria monocytogenes infections in normal mice and congenitally athymic (nude) mice. Results were compared with untreated controls and with the results obtained from a previous study of ampicillin in which this model was used. Low doses of rifampicin or rifape...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238268
更新日期:1984-01-01 00:00:00
abstract::Before appendectomy 36 adult patients were given an intravenous infusion of 500 mg of tinidazole. In the operation tissue samples were taken (blood, base of appendix vermiformis, muscle, fat) either 10, 20, 30, 60, or 120 min after cessation of infusion. The tinidazole concentrations were determined by liquid chromato...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238167
更新日期:1983-01-01 00:00:00
abstract::Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluoroura...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238212
更新日期:1983-01-01 00:00:00
abstract::Neither cefoperazone, cefotaxime, mezlocillin nor piperacillin significantly killed intraphagocytic bacteria of representative assay strains of Serratia marcescens, as determined with 55 vol% of fresh defibrinated human blood treated with 2 mg/ml of phenylbutazone, which permitted phagocytic ingestion of bacteria, but...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238173
更新日期:1983-01-01 00:00:00
abstract::Minimal bactericidal concentrations of thienamycin revealed moderate intraphagolysosomal bactericidal activity against pseudo-(PSR) and genuinely serum-resistant (NSS) assay strains of Serratia marcescens. Combinations of inhibitory and subinhibitory concentrations of thienamycin with 55 vol% of defibrinated human blo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238185
更新日期:1983-01-01 00:00:00
abstract::An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution me...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238200
更新日期:1983-01-01 00:00:00
abstract::Biliary excretion of cefaclor, a new orally active cephalosporin, was studied in vitro using an isolated rabbit liver preparation perfused for 3 h (n = 5). Under these conditions, bile recovery amounted to 2.3% of the cefaclor dose added to the circulating blood (10 mg). In humans, after oral administration of a 1-gra...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238075
更新日期:1982-01-01 00:00:00
abstract::Niridazole was shown to be an effective chemotherapeutic agent for mice infected intravenously with a niridazole-sensitive strain of Salmonella typhimurium. Death rates as well as bacterial counts per spleen were reduced, even in compromised animals. Histologic examination of spleens proved the reduction of inflammato...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238069
更新日期:1982-01-01 00:00:00
abstract::The antitumour properties of the drug N-137 were assessed in vivo in two murine T lymphoma models and two naturally metastatic hamster fibrosarcomas of Herpesvirus hominis aetiology. N-137 therapy caused a significant delay in the subcutaneous growth rate of both lymphomas (EL4 and TLX9) and in many cases completely p...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238091
更新日期:1982-01-01 00:00:00
abstract::Minimal bactericidal concentrations of trimethoprim, nalidixic acid, and nitrofurantoin revealed effective intraphagolysosomal bactericidal activity against several assay strains of Serratia marcescens as determined with phenylbutazone-treated (2 mg/ml) fresh defibrinated human blood (55 vol%), following killing of ex...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238125
更新日期:1982-01-01 00:00:00
abstract::The filamentous forms of a serum resistant Escherichia coli strain developed under in vitro exposure to subminimal inhibitory concentration of the compound LY 127935 showed a higher resistance against host defence than the nontreated control bacteria. Significantly diminished LD50 values and a longer lasting persisten...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238068
更新日期:1982-01-01 00:00:00
abstract::The pharmacokinetics and antibacterial efficacy of mezlocillin, cefotaxime, cefoperazone and the mezlocillin/cefalosporin combinations, respectively, were studied by adopting the granuloma pouch model in rats. Exudate concentrations of mezlocillin were higher after combined i.v. injection with a cefalosporin as determ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238136
更新日期:1982-01-01 00:00:00
abstract::A total of 30 hospitalized patients with upper and lower urinary tract infections were treated with cefotaxime (HR-756) by intramuscular or intravenous route. All patients had a monomicrobial infection, and the major part of bacterial isolates were gram-negative bacilli (83%) while gram-positive cocci accounted only f...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238061
更新日期:1982-01-01 00:00:00
abstract::We have tested the effectiveness of several antibiotic regimens, using a rat model of Escherichia coli experimental pyelonephritis that mimics the conditions of severe renal infections in man because the infection is acquired by the ascending route. We found that ceftriaxone, when given for 5 days to rats with severe ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238130
更新日期:1982-01-01 00:00:00
abstract::We have compared the antibacterial activities of cephalexin and cephradine against Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus (Micrococcus spp. type III), and group B streptococci (35 strains in total), using the Biophotometer. Analysis of growth curves obtained in the presence of ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238058
更新日期:1982-01-01 00:00:00
abstract::Patients with a mycologically confirmed vaginal mycosis were treated either with one 100-mg vaginal ovule of clotrimazole each for 6 days, or with one 200-mg vaginal ovule of clotrimazole each for 3 days, or with one 500-mg vaginal ovule of clotrimazole for 1 day, the ovule having been supplied in a novel, acid formul...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238151
更新日期:1982-01-01 00:00:00
abstract::The biliary excretion of tetroxoprim (TXP) was studied in 10 patients with T-tube drainage. A mean biliary peak of 32.56 +/- 7.69 micrograms/ml was observed 2-3 h after a single oral dose of 200 mg. The biliary elimination rate constant (kb) of TXP was found to be 0;056 (h-1), indicating a longer elimination from the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238097
更新日期:1982-01-01 00:00:00
abstract::Therapy of listeriosis with ampicillin was examined in two murine models with compromised defense mechanisms. In mice treated with dextran sulfate paralysing the function of the macrophage system, ampicillin was less able to reduce death rates as well as bacterial counts in the spleens than after infection of normal m...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237980
更新日期:1981-01-01 00:00:00
abstract::A review of the published literature has allowed the identification of a number of non-tubercular indications where rifampicin (trade mark Ciba-Geigy: Rimactane) has been successfully used in combination with other chemotherapeutic agents. The cases reviewed with regard to effectiveness sum 562. The most frequently co...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000238006
更新日期:1981-01-01 00:00:00
abstract::Studies are presented on the in vitro phagocytic activity of rat and human polymorphonuclear leukocytes exposed in vivo to therapeutic concentrations of doxycycline. A 32P-labelled strain of Escherichia coli served as test microbe. No significant reduction of ingestion was observed although untreated AB leukocytes tes...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000238015
更新日期:1981-01-01 00:00:00
abstract::A narcissus alkaloid, pretazettine hydrochloride (PTZ), has been shown to be active against Ehrlich ascites carcinoma. The Ehrlich cells are more sensitive to PTZ in DBA/2 mice than in Swiss mice. The therapeutic activity of the individual standard drugs in ABC (adriamycin, BCNU, and cyclophosphamide) regimen against ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237992
更新日期:1981-01-01 00:00:00
abstract::The effects of cis-[Pt(NH3)2Cl2] on the spontaneous cell-mediated cytotoxicity of human lymphoblast cell lines mediated by normal human peripheral blood lymphocytes was investigated. Direct addition of cis-[Pt(NH3)2Cl2], but not its tumor inactive trans isomer, to the in vitro spontaneous cytotoxicity assay resulted i...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237876
更新日期:1980-01-01 00:00:00
abstract::A new semisynthetic ureidopenicillin (Bay K 4999) demonstrates favorably in vitro antibacterial efficacy against human-pathogenic gram-negative rods in comparison to mezlocillin and azlocillin. A comparative paramcokinetic study was done with 10 test subjects after 30 min intravenous infusion of 4.0 g of Bay K and mez...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237887
更新日期:1980-01-01 00:00:00
abstract::Bacterial growth kinetic experiments have been performed to study the potentiating effect of trimethoprim (TMP) AND TMP derivatives on the antibacterial action of sulfonamides (SA). The TMP derivatives showed different inhibitory effects when used alone. Derivatives with decreased inhibitory activity excerted 'bacteri...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237928
更新日期:1980-01-01 00:00:00
abstract::The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The para...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237883
更新日期:1980-01-01 00:00:00
abstract::Five aminoglycoside antibiotics (AGAs)--kanamycin (KM), bekamycin (AKM), dibekacin (DKB), ribostamycin (RSM) and paromomycin (PRM)--were studied for their effects on the nonenzymic reduction of cytochrome c by FeSO4 (Yamabe's system). Their inhibitory activity was in the order: DKB greater than AKM greater than KM gre...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237880
更新日期:1980-01-01 00:00:00
abstract::Combination of 9-(S)-(2,3-dihydroxypropyl)adenine [(S)-DHPA] and 6-azauridine (AzUrd) is highly active in the selective inhibition of vaccinia virus in chick embryo cell culture. Synergic effect of this combination of compounds was not encountered in HeLa cell culture. Of the 17 analogues related to DHPA studied in th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237903
更新日期:1980-01-01 00:00:00
abstract::The in vitro activity of the new semisynthetic ureidopenicillins azlocillin (AZ) and mezlocillin (MZ), and of the new cephalosporin cefsulodin (CEF) were determined against 50 carbenicillin-sensitive (CARs) and 50 carbenicillin-resistant (CARr) P. aeruginosa clinical isolates. In the CARs group the most active antibio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237918
更新日期:1980-01-01 00:00:00
abstract::20 patients with serious infections were treated with cefazolin and tobramycin for 9--64 days. Minimal inhibitory concentration (MIC) values and minimal bactericidal concentration (MBC) values were determined for each of the 112 clinical bacterial isolates. The median cefazolin MIC/MBC was 1.56/12.5 micrograms/ml, and...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237931
更新日期:1980-01-01 00:00:00
abstract::28 patients suffering from a variety of bacterial infections have been treated with cefuroxime. 18 were cured and 6 improved during treatment. Side effects were minimal and intramuscular injection was well tolerated. Serum and urine levels well in excess of the MICs of sensitive organisms were obtained using dosages o...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237842
更新日期:1979-01-01 00:00:00
abstract::The mode of action of 5-fluorocytosine (5-FC) was studied in three isolates of pathogenic Aspergillus with varying degrees of susceptibility to the drug. Distribution studies showed that susceptibility or resistance to 5-FC was not dependent on uptake of the drug. While only a small percentage of the total 5-FC taken ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237824
更新日期:1979-01-01 00:00:00
abstract::The effect of tinidazole on several ciliates (Stylonychia muscorum, Stylonychia mytilus, Tetrahymena pyriformis, Vorticella companula) has been studied. There is a very pronounced difference in sensitivity against this drug between the free-living ciliates here investigated and certain parasitic protozoa. A high resis...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237820
更新日期:1979-01-01 00:00:00
abstract::Therapeutic effectiveness of 5-fluorocytosine (5-FC), amphotericin B (Am B) and both in combined administration were retrospectively assessed and compared with one another in 28 patients with cryptococcal meningitis. Combined administration was significantly superior to Am B alone and to 5-FC alone, and these agents w...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000237811
更新日期:1978-01-01 00:00:00
abstract::Silver sulfadiazine was found to be devoid of mutagenic potential in a sensitive mutagenicity assay using Salmonella typhimurium. In view of the close relationship between mutagenicity in this system and carcinogenicity in animals, these findings suggest that silver sulfadiazine is apparently also devoid of carcinogen...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000237765
更新日期:1978-01-01 00:00:00
abstract::One patient of sepsis by P. aeruginosa after the implanting of a ventriculoatrial valve following extirpation of an expansive intracranial process is studied. During the evolution of the septic process there appeared as associated nephrotic syndrome with histologic lesions corresponding to an acute exudative glomerula...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222085
更新日期:1977-01-01 00:00:00
abstract::Using the biophotometer with ticarcillin no persistent bactericidal effect was found against Pseudomonas aeruginosa NCTC 10490. After addition of 1.2 microgram/ml gentamicin an increase of multiplication of bacteria was observed, but not after 1.2 microgram/ml tobramycin. With 6.2 microgram/ml tobramycin bactericidal ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000222001
更新日期:1977-01-01 00:00:00